Adverse effects of the consumption of artificial sweeteners - systematic review.

Databases The following databases and respective searches were used. • Medline/PubMed: (Sweetening Agents/adverse effects OR Saccharin OR Cyclamate* OR Aspartame OR Acetosulfame OR Acesulfame) AND (Risk Factors OR Risk OR Risk Assessment OR Neoplasm* OR Carcinoma OR Cancer OR Carcinogenic) AND (Etiology/Broad[filter] OR Prognosis/Broad[filter] OR Comparative study OR Comparative studies). • Embase: ‘saccharin’/exp OR saccharin OR cyclamate* OR ‘aspartame’/exp OR aspartame OR acetosulfame OR ‘acesulfame’/exp OR acesulfame AND (‘risk’/ exp OR risk AND factors OR ‘risk’/exp OR risk AND assessment OR neoplasm* OR ‘carcinoma’/exp OR carcinoma OR ‘cancer’/exp OR cancer OR carcinogenic) AND (‘controlled study’/de OR ‘human’/de). • Cochrane Library: ‘(Sweetening Agents OR Saccharin OR Cyclamate OR Aspartame OR Acetosulfame OR Acesulfame) in title abstract keywords in Trials’. • Lilacs/Scielo: (Sweetening Agents OR Saccharin OR Cyclamate OR Aspartame OR Acetosulfame OR Acesulfame).